Infer gene regulatory networks (GRNs) from gene expression data using scalable algorithms (GRNBoost2, GENIE3). Use when analyzing transcriptomics data (bulk RNA
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Architectural decision-making framework. Requirements analysis, trade-off evaluation, ADR documentation. Use when making architecture decisions or analyzing sys
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Comprehensive patterns for creating, maintaining, and managing Architecture Decision Records (ADRs) that capture the context and rationale behind significant te
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Master proven backend architecture patterns including Clean Architecture, Hexagonal Architecture, and Domain-Driven Design to build maintainable, testable, and
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Suite of tools for creating elaborate, multi-component claude.ai HTML artifacts using modern frontend web technologies (React, Tailwind CSS, shadcn/ui). Use for
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Build content-focused websites with Astro — zero JS by default, islands architecture, multi-framework components, and Markdown/MDX support.
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Comprehensive Python library for astronomy and astrophysics. This skill should be used when working with astronomical data including celestial coordinates, phys
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Comprehensive guidance for implementing asynchronous Python applications using asyncio, concurrent programming patterns, and async/await for building high-perfo
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PyTorch library for audio generation including text-to-music (MusicGen) and text-to-sound (AudioGen). Use when you need to generate music from text descriptions
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Autonomous AI agent platform for building and deploying continuous agents. Use when creating visual workflow agents, deploying persistent autonomous agents, or
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Design patterns for building autonomous coding agents. Covers tool integration, permission systems, browser automation, and human-in-the-loop workflows. Use whe
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Autonomous agents are AI systems that can independently decompose goals, plan actions, execute tools, and self-correct without constant human guidance. The chal
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Guidelines for modern Avalonia UI layout using Zafiro.Avalonia, emphasizing shared styles, generic components, and avoiding XAML redundancy.
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Optimal ViewModel and Wizard creation patterns for Avalonia using Zafiro and ReactiveUI.
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Mandatory skills, conventions, and behavioral rules for Avalonia UI development using the Zafiro toolkit.
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Audit and rewrite content to remove AI writing patterns ("AI-isms"). Use this skill when asked to "remove AI-isms," "clean up AI writing," "edit writing for AI
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Activation-aware weight quantization for 4-bit LLM compression with 3x speedup and minimal accuracy loss. Use when deploying large models (7B-70B) on limited GP
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This skill should be used when the user asks to "pentest AWS", "test AWS security", "enumerate IAM", "exploit cloud infrastructure", "AWS privilege escalation",
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Specialized skill for building production-ready serverless applications on AWS. Covers Lambda functions, API Gateway, DynamoDB, SQS/SNS event-driven patterns, S
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Expert guidance for fine-tuning LLMs with Axolotl - YAML configs, 100+ models, LoRA/QLoRA, DPO/KTO/ORPO/GRPO, multimodal support
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Expert patterns for Azure Functions development including isolated worker model, Durable Functions orchestration, cold start optimization, and production patter
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Expert backend architect specializing in scalable API design, microservices architecture, and distributed systems.
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Comprehensive backend development guide for Node.js/Express/TypeScript microservices. Use when creating routes, controllers, services, repositories, middleware,
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Backend architecture patterns, API design, database optimization, and server-side best practices for Node.js, Express, and Next.js API routes.
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